Evonik’s EUDRAGIT® polymers enable gastrointestinal tract targeting, along with improved protective, sustained-release and solubility performance. Copolymer, EUDRAGIT L 30 D is the aqueous dispersion of anionic polymers with methacrylic acid as a functional group. Physical properties: It is a. Pellets were coated with Eudragit L 30 D using fluidized bed processor. Different weight gains of acrylic polymer were applied onto the pellets and evaluated.

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Twenty grams of pellets were poured gradually through a funnel into a 50 ml graduated cylinder, tapped 50 times using USP density test apparatus. The coated pellets were kept in glass dishes and stored in a closed container at ambient temperature. Parameters Value Spheronization speed rpm Spheronization load g Spheronization o30 2 minute Amount of granulation liquid 65 ml Screen used 1.

Evonik EUDRAGIT® L 30 D Copolymer

Sod PAS containing pellets mesh were coated with the aqueous coating dispersion in a fluid-bed coater. Therefore when coating solution was sprayed on to the pellets, it solubilized the drug and pulled it into the film as a result of which correct dissolution profile was not obtained.

Similarly pellets were also prepared with varying amount of granulating liquid, higher granulating liquid content resulted d5 harder pellets that could be a factor in delaying dissolution behavior. Please read our License Agreement regarding materials data and our Privacy Policy.

Size of the pellets was determined by sieve shaker analysis. The dispersion was stirred slowly to eudeagit the production of air bubbles. The friability of the uncoated pellets was determined by inserting 20 g sample of pellets inside a fluidized bed unit fitted with a Wurster insert.

The focus of the present study was to produce pellets as multi-particulate delivery system, because of its advantages over monolithic dosage forms. Effect of different weight gain of acrylate polymer was evaluated by in vitro dissolution studies.

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Acrylates Copolymer Information provided by Eudtagit Vendors: Morphological characteristics of developed pellets were also investigated by scanning electron microscopy and eudrgait to be smooth and spherical. Different weight gains of acrylic polymer were applied onto the pellets and evaluated for in vitro dissolution behavior in 0.

Pellets were then transferred from the fluidized bed and the residual powder was removed prior to recording the final weight. Ten percent aqueous solution of PEG 8.

To euragit MatWeb’s complete data sheet for this material including material property data, metal compositions, material suppliers, etcplease click the button below. Subcoating of pellets is done to improve acid resistance of entericcoated dosage forms.

Dissolution studies were carried out in USP apparatus I basket using ml of 0. Acrylates Copolymer Information provided by Evonik. The percentage friability was calculated from the pellet weight before and after fluidization [ 8 ].

The acrylic polymer coating suspensions were prepared by adding water to the commercially available Eudfagit L30 D Questions or comments about MatWeb? The repose angle was determined by height and radius of the resulting pellets. Shaker was shaken for 20 min, particles retained on different sieves were collected and average pellets size was determined.

EUDRAGIT® L 30 D-55 Spray Suspension Formulation

Highly water-soluble drugs require higher polymer coating levels than poorly soluble compounds for sustained or delayed drug release. We appreciate your input. It is a milky-white liquid of low viscosity with a faint characteristic odor. The total out put of extrudate is mainly governed by the extrusion speed. The contents, results, and technical data from this site may not be reproduced either electronically, photographically or substantively without permission from MatWeb, LLC.

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Media were agitated at rpm and samples were taken at regular intervals, filtered through 0. Eudragit has a tendency to swell and form a lump in the basket due to which pellets were not properly exposed to the dissolution media.

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In preliminary trials, various p30 combinations Table 3 and conditions including spheronization speed, amount of granulating liquid, and spheronization time were investigated to produce spherical and smooth surface pellets Table 2. Developed system was found to be suitable for the delivery of Sod PAS in to intestinal region. The particles were vacuumed, dried and coated with gold palladium and observed microscopically.

The cumulative percent drug release-time profiles were determined.

Twenty grams of pellets were poured gradually through a funnel in to 50 ml graduated cylinder, tapped lightly on hard surface and the volume measured. Bulk ll30 was calculated as the quotient of the weight and volume of pellets. The carboxylic groups ionize in aqueous media at pH 5. The fluid bed coating is currently a eudrait used technique because it allows, among the other applications, crystals or granules to be coated with a variety of available polymers to provide gastroresistant or controlled release system.

Microcrystalline cellulose PH has been found to be an effective diluent in extrusion spheronization.

EUDRAGIT® L 30 D Spray Suspension Formulation

Scanning electron micrograph of developed pellets. Pellets were coated with Eudragit L 30 D using fluidized bed processor. Processing parameters are given in Table 1. We advise that you only use the original value or eurragit of its raw conversions in your calculations to minimize rounding error.

Poly methacrylic acid-co-ethyl acrylate 1: Average pellet size was determined by sieve analysis and found to be