Owing to pseudoexfoliation glaucoma’s prevalence and severity, gonioscopy should be performed to assess for pigment deposition and a Sampaolesi’s line. Sampaolesi line is a sign which may be observed during a clinical eye examination. During gonioscopy if an abundance of brown pigment is seen at or anterior. The Glaucomas. Volume II – Open Angle Glaucoma and Angle Closure Glaucoma. Authors; (view affiliations). Roberto Sampaolesi; Juan Roberto Sampaolesi.

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Reducing the Release of Pigment Methods for decreasing pigment particles in the anterior chamber in exfoliation syndrome and pigment dispersion syndrome.

Sampaolesi line – Wikipedia

Pseudoexfoliation syndrome does, however, significantly predispose those affected to the development of increased IOP, and it results in glaucoma in 15 percent to 30 percent of cases.

Vitreous loss is times more common in these eyes. Privacy Policy Terms of Use. Create a free personal account to download free article PDFs, sign up for alerts, and more.

Ocular Echometry in the Diagnosis of Congenital Glaucoma

PDS is more common in younger, myopic patients, and is often bilateral. The central zone is usually well demarcated and can have curled edges.

The lysyl oxidase-like protein 1 LOXL1 gene is important for elastin metabolism. If medications and laser treatment do not control IOP adequately, a guarded filtration procedure may be performed. The classic sign of PXF is the visualization of white pseudoexfoliative material on the pupil margin and on the anterior lens surface with a clear intermediate zone due to rubbing off by the iris. The trabecular meshwork becomes clogged resulting in reduced aqueous outflow, raised IOP and secondary glaucoma.

Patients receiving laser trabeculoplasty should also be reexamined in three to six weeks. This brief review will discuss the pathophysiology, clinical course and signs, differential diagnosis, and treatment sampalesi of this disease. Sign in to make a comment Sign in to your personal account.


Pseudoexfoliative Glaucoma

Pseudoexfoliative material can be identified pre-clinically with transmission electron microscopy which shows fibrillar elastotic material. We use cookies to offer a better user experience and to analyze site traffic. Patient complained of a painless, gradual loss of vision OS over several months. Exercise and reversed pupillary block in pigmentary glaucoma. Various imaging studies can also be used to detect and monitor glaucomatous changes in the retinal nerve fiber layer and glaucomq disc.

Cyclodestruction of the ciliary body last resort. sampaolesl

This would allow early treatment and prevention of glaucoma, or at least reduced risk of developing advance glaucoma. The cyclopentolate provocative test in suspected or untreated open-angle glaucoma: Iris sphincter sampqolesi defects in exfoliation syndrome result from the dispersion of pigment into the anterior chamber.

Pseudoexfoliation syndrome is a systemic disease with primarily ocular manifestations characterized by deposition of whitish-gray protein on the lens, iris, ciliary epithelium, corneal endothelium and trabecular meshwork.

In cases of PXF with glaucooma angle closure due to zonular laxity, the key to distinguishing it from PACG is the asymmetry in anterior chamber depth, as well as the presence of pseudoexfoliative material. Interested in sharing tips with your colleagues? This article is from June and may contain outdated material. Patients with uncontrolled glaucoma are poor candidates for laser iridotomy, since clearing of the meshwork and the subsequent IOP reduction requires a long time after the laser iridotomy.

Although attempts at identifying the material have been unsuccessful, pathologic study has revealed that the lens epithelium, trabecular meshwork, iris, ciliary processes, conjunctiva and periocular tissue are its source.

Quantification of aqueous melanin granules in primary pigment dispersion syndrome. Liberation of iris pigment in eampaolesi anterior chamber. Purchase access Subscribe to JN Learning for one year.


Similar to the pathophysiology of pseudoexfoliation glaucoma, material accumulates in the trabecular meshwork, leading to progressive trabecular dysfunction and increased IOP. Sign in to customize your interests Sign in to your personal account.

: pseudoexfoliation glaucoma

Prince AM, Ritch R. Methods for decreasing pigment particles in the anterior chamber in exfoliation syndrome and pigment dispersion syndrome. Patients with pigment dispersion syndrome or pigmentary glaucoma can also experience sudden IOP spikes after pupillary dilation. Patients with pseudoexfoliation syndrome and no evidence of glaucoma are generally not treated, but they should be followed every six to 12 months as they have an increased risk of developing glaucoma.

Wang et al 25 conducted a review of 23 patients with pigment dispersion syndrome and elevated IOP who had no or only mild glaucomatous damage and who had undergone laser iridotomy.


Page Discussion View form View source History. Such eyes have weak zonular attachments as well, also complicating cataract surgery. The melanin dispersion is from atrophy of the iris pigment epithelium. The significance of pigment for the result of the cyclopentolate provocative test in suspected or untreated open-angle glaucoma. Decreasing pupillary movement may reduce iridolenticular friction and thus avert the liberation of iris pigment, slow the progression of trabecular blockage, and perhaps allow the meshwork to clear.

Glaucoma is rare with true exfoliation or capsular delamination. One way of distinguishing this from primary angle closure is the relatively deep anterior chamber on the other likely less affected side. POAG should be considered in the differential.